Identify which sounds remain audible
Check whether the Plex programme itself still has sound while a browser notification or another application does not. Plex’s settings reference describes Exclusive Audio as sending only the media audio to the chosen device, bypassing the normal system mixer.
Note the selected output device as well as the setting. A USB audio interface, television over HDMI and built-in speakers are different destinations. Silence on one destination does not establish that every output or every application has failed. Keep the same destination for the first comparison.
Keep format and application goals separate
An exclusive audio route and a shared desktop route can have different purposes. The right choice depends on what you are trying to hear, not on a universal rule that one mode is always a repair. Record the original preference so the home-theatre setup can be restored if needed.
If the comparison does not explain the silence, give Plex support the operating system, HTPC version, chosen audio device and which apps remain audible during playback. Include whether changing Exclusive Audio affected the result. That evidence distinguishes a documented mixer choice from an application-volume, output-selection or hardware problem.
